ML-031 ethyl-2'-methoxychalcone 1-50 µM) and inhibits A23187-induced

1-50 µM) and inhibits A23187-induced calcium influx in mast cells

and 8 with IC50 for 55

4-triazol-1-yl)methyl]phenyl]-2-methylpropanenitrile

InChi: InChI=1S/C28H31NO2

Smiles: COC(=O)CCC[C@H](O)[C@H](O)CO

ML-031 ethyl-2'-methoxychalcone 1-50 µM) and inhibits A23187-inducedML 031 is an agonist of S1P2 with EC50 value of 1 M . Sphingosine 1 phosphate (S1P) is a bioactive lysophospholipid mediator mainly released from activated platelets and implicated in many biological responses, such as cell proliferation, migration, survival, and differentiation . Sphingolipids belong to a family of bioactive molecules with cell signaling properties. Sphingosine 1 phosphate (S1P) is widely expressed on various tissues and cell types.