Chlorpyrifos 10 TFA KSI-3716 effectively blocks complex formation

KSI-3716 effectively blocks complex formation in a dose dependent manner (IC50=0

Smiles: CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CC2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N[C@@H](CC2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(=O)NCC(N)=O

Smiles: COC1C=CC(=CC=1)N1C(=NN=C1C1C=CN=CC=1)SCCCN1C(=O)C2C=CC=C3C=CC=C(C3=2)C1=O

is a potent and orally active Leukocyte elastase (HLE) inhibitor

Formula: C26H29N5O3

Chlorpyrifos 10 TFA KSI-3716 effectively blocks complex formationChlorpyrifos is an organophosphate insecticide that is classified as a phosphorothionate. The oxon metabolite of Chlorpyrifos is an inhibitor of acetylcholinesterase (AChE), affecting neurological function in insects, humans, and other animals. The Chlorpyrifos oxon (CPO) metabolite is hydrolyzed by the plasma enzyme paraoxonase 1 (PON1), and susceptibility to neurotoxicity associated with CPO exposure is mitigated by PON1 overexpression. Product