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dBET6 is well tolerated
CH4O3S/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36
and 30 mg/kg) to high-fructose fed db/+ mice results in significant inhibition of hepatic fatty acid synthesis (FAS) for all three doses
Smiles: CN1C=NC(CN2C=CC3C=CC(CNCC4NC5=CC=CC=C5C=4C4NC(=O)C5C=CC(O)=CC=54)=CC2=3)=C1
Formula: C2H4N6
CHMFL-PI3KD-317 Size:Contact [email protected] for quotation dBET6 is well toleratedCHMFL PI3KD 317 is a highly potent, selective and orally active PI3K inhibitor, with an IC50 of 6 nM, and exhibits over 10 1500 fold selectivity over other class I, II and III PIKK family isoforms, such as PI3K (IC50, 62. 6 nM), PI3K (IC50, 284 nM), PI3K (IC50, 202. 7 nM), PIK3C2A (IC50, >10000 nM), PIK3C2B (IC50, 882. 3 nM), VPS34 (IC50, 1801. 7 nM), PI4KIIIA (IC50, 574. 1 nM) and PI4KIIIB (IC50, 300. 2 nM). CHMFL PI3KD 317 inhibits PI3K mediated Akt
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