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Smiles: O=C(NC1=NC=C(CCNC2=NC=NC3C=CSC=32)S1)NC1=CC(Cl)=CC=C1
Smiles: COC1C=C(C[C@@H]2[C@@H](CC3C=C(OC)C(=CC=3)OC)COC2=O)C=CC=1O
Smiles: N[C@@H](CN1C=C(F)C(=O)NC1=O)C(O)=O
Advances in clinical cardiology
NLG919 was dosed to mice orally or through IP injection with different dose and schedule
NB-598 Hydrochloride alafenamide hemifumarate Smiles: O=C(NC1=NC=C(CCNC2=NC=NC3C=CSC=32)S1)NC1=CC(Cl)=CC=C1NB 598 is a potent competitive inhibitor of squalene epoxidase (SE). NB 598 suppresses triglyceride biosynthesis through the farnesol pathway. NB 598 suppresses the secretion of cholesterol and triacylglycerol and simultaneously reduces apolipoprotein B in HepG2 cells. NB 598 reduced basolaterally secreted radioactivity in cholesterol, cholesterol ester, PL and TG. Furthermore, NB 598 suppressed the basolateral secretion of apolipoprotein (apo) B.
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