PFI-2 (hydrochloride) - CAS# 2509095-55-8 21209 45 μM and 1

45 μM and 1

is a potent and selective Pyruvate kinase M2 (PKM2) activator with EC50 ~38 nM

8'aR)-1-(2-{4-[2-(2

PF-06409577 is orally bioavailable AMPK activator with EC50 of 7 nM for α1β1γ1 in the TR-FRET assay and it shows no detectable inhibition of hERG in a patch-clamp assay (100 μM) and was not an inhibitor (IC50 > 100 μM) of the microsomal activities of major human cytochrome P450 isoforms

InChiKey: HIXSPVQXXDULHS-UHFFFAOYSA-N

PFI-2 (hydrochloride) - CAS# 2509095-55-8 21209 45 μM and 1Product information CAS Number: 2509095 55 8 Molecular Weight: 535. 98 Formula: C23H26ClF4N3O3S Chemical Name: 8 fluoro N [1 oxo 1 (pyrrolidin 1 yl) 3 [3 (trifluoromethyl)phenyl]propan 2 yl] 1,2,3,4 tetrahydroisoquinoline 6 sulfonamide hydrochloride Smiles: Cl. O=C(C(CC1C=CC=C(C=1)C(F)(F)F)NS(=O)(=O)C1=CC(F)=C2CNCCC2=C1)N1CCCC1 InChiKey: ZADKZNVAJGEFLC UHFFFAOYSA N InChi: InChI=1S C23H25F4N3O3S. ClH c24 20 13 18(12 16 6 7 28 14 19(16)20)34(32,33)29