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LDN-214117 - CAS# 1627503-67-6 60245 2(6):799-803

SKU: 67296372339

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Description

2(6):799-803

（2015）Proc Natl Acad Sci USA

and resistance to both chemotherapy and radiotherapy

2013 Sep 4

is non-toxic in SCID mice

LDN-214117 - CAS# 1627503-67-6 60245 2(6):799-803LDN 214117, CAS No. 1627503 67 6, is a selective and potent ALK2 inhibitor. LDN 214117 inhibited ALK2 most, with a biochemical IC50 of 24 nM. There are currently no effective therapies for fibrodysplasia ossificans progressiva (FOP), a debilitating and progressive heterotopic ossification disease caused by activating mutations of ACVR1 encoding the BMP type I receptor kinase ALK2. LDN 214117 shows a high degree of selectivity for ALK2 and low

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