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and thus topoisomerase II poisons will be less inhibitory in the K/VP
BMS-232632
S)-AHPC based VHL ligand and 4-unit PEG linker
Smiles: OC(COP(O)(O)=O)C=O
Structural studies revealed that the tert-butyl amine of UNC2170 anchors the compound in the methyl-lysine (Kme) binding pocket of 53BP1
Phthalimide-PEG4-PDM-OTBS CT007093 and thus topoisomerase II poisonsPhthalimide PEG4 PDM OTBS is a PROTAC linker, which refers to the PEGs composition. Phthalimide PEG4 PDM OTBS can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin proteasome system to selectively degrade target proteins. Product information Molecular Weight: 536. 73