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InChi: InChI=1S/C27H36N4O5S/c1-6-37(34
and may inspire novel drug discovery efforts aimed at the development of drugs targeting oncogenic RAS
Epub 2019 Jun 18
103883-03-0
7-Dimethoxy-N-phenylquinazolin-4-amine
GW791343 dihydrochloride 022 InChi: InChI=1S/C27H36N4O5S/c1-6-37(34GW791343 dihydrochloride is a P2X7 allosteric modulator; exhibits species specific activity and acts as a negative allosteric modulator of human P2X7 (pIC50 = 6. 9 7. 2). IC50 value: 7 (pIC50) Target: P2X7 in vitro: In cells expressing human P2X7 receptors, GW 791343 inhibits agonist stimulated ethidium accumulation in both sucrose and NaCl buffer. In NaCl buffer, GW 791343 reduces the maximal response to both ATP and BzATP, but there is little effect
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