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Chemical Name: (Z)-4-(4-((5-(4
The mitogen-activated protein kinase (MAPK)/ERK pathway is often upregulated in a variety of tumor cell types and plays a key role in tumor cell proliferation
217-225 (2005)
To correlate these in vivo responses with the molecular target of interest
Alantolactone induces apoptosis in HepG2 cells in a dose-dependent manner
A-966492 Size:2mg solid Chemical Name: (Z)-4-(4-((5-(4A 966492 is a potent PARP inhibitor, which displayed excellent potency against the PARP 1 enzyme with a K(i) of 1 nM and an EC(50) of 1 nM in a whole cell assay. In addition, A 966492 is orally bioavailable across multiple species, crosses the blood brain barrier, and appears to distribute into tumor tissue. It also demonstrated good in vivo efficacy in a B16F10 subcutaneous murine melanoma model in combination with temozolomide and in an MX 1 breast