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1 μM in intact leukocytes and human whole blood
46-13)31(42)23(7)48-26/h18-26
COX-2-IN-2 shows no COX-1 inhibition even at 100μM
and the serum levels of histamine and several cytokines in vitro and in vivo studies
Gubellini P
DOV-216, 303 Free Base cin M1 1 μM in intact leukocytesDOV 216,303 (Free Base) is a potent triple serotonin, norepinephrine, and dopamine reuptake inhibitor, with IC50 values of 14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT, respectively. Has antidepressant like effects and increases monoamine release in the prefrontal cortex of olfactory bulbectomized (OBX) rats. Product information CAS Number: 66504 40 3 Molecular Weight: 228. 12 Formula: C11H11Cl2N Chemical Name: 1 (3,4 dichlorophenyl) 3