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especially the alpha-1 subunit
Balligand JL
E-7449 (30 or 100 mg/kg
InChiKey: OPQRFPHLZZPCCH-PGMHBOJBSA-N
pyruvate tolerance
BLU-9931 - CAS# 1538604-68-0 255 especially the alpha-1 subunitBLU 9931, CAS No. 1538604 68 0, is a potent and irreversible small molecule inhibitor of FGFR4, as a targeted therapy to treat patients with HCC whose tumors have an activated FGFR4 signaling pathway. BLU 9931 is exquisitely selective for FGFR4 versus other FGFR family members and all other kinases. BLU 9931 shows remarkable antitumor activity in mice bearing an HCC tumor xenograft that overexpresses FGF19 due to amplification as well as a liver tumor