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InChi: InChI=1S/C21H36O10/c1-19(2
CAS Number: 477313-09-0
Formula: C29H37Cl3N6O
CAS Number: 360-65-6
4-benzodiazepin-1-yl)acetohydrazide
ARL 17477 dihydrochloride B2 Ligand InChi: InChI=1S/C21H36O10/c1-19(2ARL 17477 dihydrochloride is a selective and potent neuronal nitrogen oxide synthase (nNOS) inhibitor with IC50 values of 1 and 17M for nNOS and endothelial NOS, respectively . Neuronal NOS (nNOS) plays an important role in the development of ischaemic brain necrosis while endothelial NOS (eNOS) protects brain tissue through increasing ischaemic regional cerebral blood flow . In rats after transient MCA occlusion, ARL 17477 (1mg kg, 3mg kg and 10mg
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