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Formula: C22H21ClN2O3
4'-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide
InChiKey: NEXGBSJERNQRSV-UHFFFAOYSA-N
10(7):e0131464
LGK974 is a highly potent
RepSox - TGF-β Type I Receptor ALK5 Inhibitor. CAS# 446859-33-2 0273 Formula: C22H21ClN2O3RepSox (E 616452 or SJN 2511), CAS No. 446859 33 2, is a highly potent, selective inhibitor of the TGF type I receptor ALK5 with IC50 of 23 nM and 4 nM for ATP binding to ALK5 and ALK5 autophosphorylation, respectively. It has good selectivity for ALK5 over a range of kinases, including p38 MAPK, JNK1 and GSK3 (IC50 > 16 M). RepSox is able to successfully replace Sox2 in reprogramming by inhibiting transforming growth factor (Tgf ) signaling, which in
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