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pii: /j/jcim
This leads to an inhibition of the growth of malignant B cells that overexpress BTK
It also significantly inhibits JAK2 V617F
CO-1686 (50 mg/kg bid
displays potent growth-inhibitory activity against human head and neck cancer cells in vitro and in vivo
Dabrafenib - CAS# 1195765-45-7 size:2mg solid pii: /j/jcimDabrafenib, CAS No. 1195765 45 7, also known as GSK2118436 , is an orally bioavailable inhibitor of B raf (BRAF) protein with potential antineoplastic activity. Dabrafenib selectively binds to and inhibits the activity of B raf, which may inhibit the proliferation of tumor cells which contain a mutated BRAF gene. B raf belongs to the the raf mil family of serine threonine protein kinases and plays a role in regulating the MAP kinase ERKs signaling
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