bpV(phen) trihydrate 310 and Orally Bioavailable Inhibitors of

and Orally Bioavailable Inhibitors of the Mammalian Target of Rapamycin (mTOR)

also known as S1RA and MR390

Scicchitano M

Talampanel (IVAX) has neuroprotective effects in rodent stroke models

The synaptic density is reduced by Piericidin A treatment in P301S+/+ mice

bpV(phen) trihydrate 310 and Orally Bioavailable Inhibitors ofbpV(phen) trihydrate, a insulin mimetic agent, is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor with IC50s of 38 nM, 343 nM and 920 nM for PTEN, PTP and PTP 1B, respectively. bpV(phen) trihydrate inhibits proliferation of the protozoan parasite Leishmania in vitro. bpV(phen) trihydrate strongly induces the secretion of a large number of chemokines and pro inflammatory cytokines, and it activates a Th1 type pathway (IL 12, IFN).