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Stephen Willingham
2019 Feb 1
also known as NCGC00242364 and ANTAG3
Chemical Name: 4-oxo-1
57(6):2611-22
CC-115 - CAS# 1228013-15-7 Catalog No.:M6483-10 Stephen WillinghamCC 115, CAS No. 1228013 15 7, is a dual inhibitor of DNA dependent protein kinase (DNA PK) and mammalian target of rapamycin (mTOR), with potential antineoplastic activity. CC 115 binds to and inhibits the activity of DNA PK and both raptor mTOR (TOR complex 1 or TORC1) and rictor mTOR (TOR complex 2 or TORC2), which may lead to a reduction in cellular proliferation of cancer cells expressing DNA PK and TOR. DNA PK, a serine threonine kinase and a
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