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Non-hinge-binding pyrazolo[1
2010 Feb 11
CAS Number: 1092443-52-1
CS-0015612
Formula: C17H20N6O4S
AZ 628 Size:Solid 2 mg Non-hinge-binding pyrazolo[1AZ 628 is a selective, orally available Raf inhibitor with excellent pharmacokinetic properties and robust tumor growth inhibition in xenograft studies ( (IC50 values are 29, 34 and 105 nM for c Raf1, B RafV600E and wild type B Raf, respectively). AZ 628 inhibits growth, and induces cell cycle arrest and apoptosis in colon and melanoma cell lines with the B RafV600E mutation. Product information CAS Number: 878739 06 1 Molecular Weight: 451. 52