CONC(=O)C1=CC=C(F)C(F)=C1NC1=CC=C(I)C=C1F](https://cdn.shopify.com/s/files/1/0389/1897/9723/products/BX-471__ZK-811752__structure.gif?v=1742668332)
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Smiles: OC[C@@H](O)CONC(=O)C1=CC=C(F)C(F)=C1NC1=CC=C(I)C=C1F
MEK5 enzyme
InChi: InChI=1S/C24H28N4O4/c1-28(2)8-9-31-23-12-16(19-13-25-26-14-19)4-6-21(23)27-24(29)18-10-17-11-20(30-3)5-7-22(17)32-15-18/h4-7
Molecular Weight: 640
57(2):110-3
BX-471 - CAS# 217645-70-0 60310 Smiles: OC[C@@H](O)CONC(=O)C1=CC=C(F)C(F)=C1NC1=CC=C(I)C=C1FBX 471, CAS No. 217645 70 0, also known as ZK 811752, is a potent, selective non peptide CCR1 antagonist (Ki = 1 nM for human CCR1). BX 471 exhibits 250 fold selectivity for CCR1 over CCR2, CCR5 and CXCR4. BX 471 was developed Berlex and its parent company, Schering AG. BX 471 is the lead in a series of non peptide chemokine receptor 1 (CCR1) antagonists, for the potential treatment of autoimmune diseases, in particular multiple sclerosis (MS). In
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