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Smiles: CC(C)(C)OC(=O)COCCOCCOCCCCCCOCC1C=CC=CC=1
Epub 2010 Apr 26
Substituent effects of N-(1
an inhibitor of PC-PLC and sphingomyelin synthase
Solubility: DMSO: 55
CX-5461 dihydrochloride Catalog No.:M14526-2 Smiles: CC(C)(C)OC(=O)COCCOCCOCCCCCCOCC1C=CC=CC=1CX 5461 dihydrochloride is a potent and orally bioavailable inhibitor of Pol I mediated rRNA synthesis, with IC50s of 142 nM in HCT 116, 113 nM in A375, and 54 nM in MIA PaCa 2 cells, and shows little or no effect on Pol II (IC50 25 M). Product information Molecular Weight: 586. 54 Formula: C27H29Cl2N7O2S Chemical Name: 4 (4 methyl 1,4 diazepan 1 yl) N [(5 methylpyrazin 2 yl)methyl] 8 oxo 11 thia 1,3 diazatetracyclo[8. 7. 0. 0,. 0,]heptadeca