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ASP2215 inhibited the growth of MV4-11 cells
Smiles: CC1=CC=C(C=NNC(=O)C2=CC=CC=C2OC2C=CC=CC=2)O1
16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H
and consistently
Targeted Degradation of Proteins Localized in Subcellular Compartments by Hybrid Small Molecules
AMG 232 Catalog No.:M8600-2 ASP2215 inhibited the growth ofAMG232 is an extremely potent MDM2 inhibitor (SPR KD = 0. 045 nM, SJSA 1 EdU IC50 = 9. 1 nM), with remarkable pharmacokinetic properties and in vivo antitumor activity in the SJSA 1 osteosarcoma xenograft model (ED50 = 9. 1 mg kg). AMG232 is currently under clinical development. Product information CAS Number: 1352066 68 2 Molecular Weight: 568. 55 Formula: C28H35Cl2NO5S Synonym: AMG232 AMG 232 Chemical Name: 2 [(3R,5R,6S) 5 (3 chlorophenyl) 6 (4
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