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LY-3090314 enhances the efficacy of cisplatin and carboplatin in solid tumor cancer cell lines in vitro
and matrix metalloproteinase activities of CRC cell lines
The AUC is good in dogs and rats
InChi: InChI=1S/C21H24N4O3/c1-23-17-12-15(22-20(26)14-8-4-5-9-19(14)28-3)16(25-10-6-7-11-25)13-18(17)24(2)21(23)27/h4-5
TAS-116 triggers enhanced in vivo anti-MM activities
PAI-039 - CAS# 393105-53-8 size:2mg solid LY-3090314 enhances the efficacy ofPAI 039, CAS No. 393105 53 8, is a novel plasminogen activator inhibitor 1 (PAI 1) inhibitor. The pharmacokinetic profile of PAI 039 indicated an oral bioavailability of 43 + 15. 3% and a plasma half life of 6. 2 + 1. 3 h. PAI 039 is an orally active prothrombolytic drug that inhibits PAI 1 and accelerates fibrinolysis while maintaining normal coagulation in a model of coronary occlusion . PAI 039 exerts antithrombotic efficacy in rat models of
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