Throw in a Sheoldred, the Apocalypse to start gaining life with your card draw, and you can do some nasty stuff
Myrkul, Lord of Bones (Check it out here) was built as the leader of a Midrange and Constellation deck that ran a bunch of dorks with ETB abilities for value (like Liliana's Specter and Archon of Cruelty), sacrificed them for value (High Market and Dockside Chef), netted a return as an enchantment to trigger another ETB for it and constellation dorks (like Underworld Coinsmith and Eidolon of Blossoms) and then added in some ramp, answers, card flow, and called it a deck
The blogger went on to engage in Flip It or Rip It at GP Washington a week later
Then, whenever he quests, you can bring out an item from your hand for free
Juju Bubble is a one mana Artifact that allows you to pay two mana to gain one life
The effect applies to itself at the very least, and you can even circumvent the restriction with cutesy tricks like Mycosynth Lattice and Liquimetal Torque