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) protects bone and cartilage from degradation
It has minimal inhibition of UCHL-1
and the IC50 is less than 1 pM in most cases
SGI-1027 may have the potential for use in epigenetic cancer therapy
InChi: InChI=1S/C14H14ClFN8/c1-7-3-11(24-23-7)21-13-10(15)6-19-14(22-13)20-8(2)12-17-4-9(16)5-18-12/h3-6
AK-7 - SIRT2 Inhibitor. CAS# 420831-40-9 size:2 mg solid ) protects bone and cartilageAK 7, CAS No. 420831 40 9, is a cell and brain permeable, selective sirtuin SIRT2 inhibitor (IC50 ~15. 5 M). AK 7 displays no effect on SIRT1 or SIRT3. It diminishes neuronal cell death induced by mutant huntingtin fragment. It also down regulates cholesterol biosynthetic gene expression and reduces total cholesterol levels in neurons in vivo. In two genetic mouse models of Huntingtons disease, AK 7 treatment resulted in improved motor function,
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