PP7 Catalog No.:M29488-C HCl) blocks agonist-suppressed spontaneous Ca2+

HCl) blocks agonist-suppressed spontaneous Ca2+ oscillations (IC50=34 nM) and in an intact hippocampal slice preparation (IC50=46 nM)

Smiles: CCC(C)C1NC(=O)C(CC(C)C)NC(=O)C(CCCCN)NC(=O)C(CC(C)C)NC(=O)C(CC(N)=O)NC(=O)C(CCCNC(N)=N)NC(=O)C(CC2C=CC=CC=2)NC(=O)C2CCCN2C(=O)C(CCSC)NC(=O)CNC(=O)C(NC(=O)C(CC(N)=O)NC(=O)C(CC2=CNC=N2)NC(=O)C(CC2C=CC(O)=CC=2)NC(=O)C2CSCC(NC(=O)C(CCCCN)NC(=O)C(N)CC(C)C)C(=O)NC(CC3C=CC(O)=CC=3)C(=O)NC(CCC(N)=O)C(=O)NC(CC3=CNC=N3)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(C(C)C)C(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(CSSCC(NC(=O)CNC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC1=O)C(=O)NC(CO)C(=O)NC(CO)C(=O)NC(CO)C(=O)NC1CSSCC(NC(=O)C(CCCCN)NC(=O)C(CC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(NC(=O)C(CCC(O)=O)NC(=O)C(CO)NC1=O)C(C)O)C(=O)NC1CSSCC(NC(=O)C(CCCNC(N)=N)NC(=O)C(CC(O)=O)NC(=O)C(NC(=O)C(CO)NC1=O)C(C)O)C(=O)NC(CC(N)=O)C(=O)NC(CCCCN)C(O)=O)C(=O)NC(CC1=CNC=N1)C(=O)NC(CCCNC(N)=N)C(=O)NC(CC(O)=O)C(=O)NC(CCSC)C(=O)NC(CCCCN)C(=O)NC(CC1C=CC=CC=1)C(=O)N2)C(C)O

t(1/2beta) of 256 min and 264 min

The combination of XL184 (20 mg/kg once daily for first 3 days

Smiles: CNC1C=CC(/C=C/C2=C(F)C=CC=C2Cl)=CC=1

PP7 Catalog No.:M29488-C HCl) blocks agonist-suppressed spontaneous Ca2+PP7 is a potent PB1 PB2 interaction inhibitor with an IC50 of 8. 6 M, and their inhibition against viral polymerase activity (IC50=9. 5 M). PP7 shows antiviral activities against influenza A virus (IAV), including A(H1N1)pdm09 (EC50=1. 4 M), A(H7N9) and A(H9N2) subtypes. Product information CAS Number: 433238 84 7 Molecular Weight: 377. 22 Formula: C18H14Cl2N2O3 Chemical Name: (4E) 1 (3,4 dichlorophenyl) 4 [(4 ethoxyphenyl)methylidene]pyrazolidine 3,5