Alfacalcidol 3306 ) inhibits tumor growth by

) inhibits tumor growth by 49% and 74 % in HCT-116 xenografts

Smiles: CN(CC#C)C1=C(C=NN1C1=NN2CCCCC2=C1Cl)C#N

31)32)23(5)24(6)28(26)33-29/h20-22H

Chemical Name: (6R)-6-[(1R

1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-3-nitrophenyl)sulfonyl)benzamide

Alfacalcidol 3306 ) inhibits tumor growth byAlfacalcidol is an active metabolite of Vitamin D, which performs important functions in regulation of the calcium balance and the bone metabolism. Alfacalcidol is Vitamin D hormone analog which is activated by the enzyme 25 hydroxylase in the liver for systemic and in osteoblasts for local D hormone actions. It possesses a unique pattern of pleiotropic effects on, e. g. gut, bone, pararthyroids, muscle and brain. Alfacalcidol is superior to plain