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GSK040 shows more than 5000-fold selectivity for BET BD2 over BET BD1 (pIC50=4
7-dihydroxy-4-oxo-4H-chromen-3-yl]oxy}-4
24 hours) and both p-AKT Ser473 and p-mTOR Ser2448 are also decreased in BGT226-treated cell lines
Solubility: DMSO : 125 mg/mL (263
and competitively inhibits dihydrofolate reductase (DHFR) with a Ki of 3
Tankyrase Inhibitors (TNKS) 49 Size:Contact [email protected] for quotation GSK040 shows more than 5000-foldTankyrase Inhibitors (TNKS) 49 is a potent, selective and orally bioavailable inhibitor of tankyrase with IC50 value of 0. 1nM . Tankyrase 1 and tankyrase 2 are members of PARP family. They can use NAD+ as substrates to transfer ADP ribose polymers onto tagert proteins. The tankyrase are found to bind to PARSylate axin proteins which are the negative regulator of Wnt pathway. It makes tankyrase to be targets in treatment for adenomatous polyposis