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as well as reduction in FT
InChi: InChI=1S/C20H30O3/c1-14-5-8-17-19(2
Smiles: COCCOCCOCCOCCOCCOCCOCCN
5-dioxopyrrolidin-1-yl]benzoate
CAS Number: 153504-70-2
CDK12-IN-2 andicarboxylic acid as well as reduction inCDK12 IN 2 is a potent, selective and nanomolar CDK12 inhibitor (IC50=52 nM) with good physicochemical properties. CDK12 IN 2 is also a strong CDK13 inhibitor due to CDK13 is the closest homologue of CDK12. CDK12 IN 2 shows excellent kinase selectivity for CDK12 over CDK2, 9, 8, and 7. CDK12 IN 2 inhibits the phosphorylation of Ser2 in the C terminal domain of RNA polymerase II. CDK12 IN 2 can be used an excellent chemical probe for functional studies
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