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KAN0438757 is a potent and selective inhibitor of the metabolic kinase PFKFB3 (6-Phosphofructo-2-Kinase/Fructose-2
InChi: InChI=1S/C19H18N4O4/c24-17-14(8-4-9-20-17)18(25)21-10-5-11-22-19(26)15-12-16(27-23-15)13-6-2-1-3-7-13/h1-4
ErSO (10 or 40 mg/kg
5-tetrakisphosphate [Ins (1
]tetracosa-1(24)
3, 4-DAA Size:Contact [email protected] for quotation KAN0438757 is a potent andN (3,4, Dimethoxycinnamoyl) anthranilic acid (3,4 DAA) is a synthetic derivative of the tryptophan metabolite anthranilic acid . Degradation of the essential amino acid Trp by indoleamine 2,3 dioxygenase (IDO) plays an important role in immunity. IDO has been implicated in immune modulation through limiting T cell function and engage mechanisms of immune tolerance. Activation of IDO has been observed during tumor development, helping malignant cells
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