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Chemical Name: 7-fluoro-12-methyl-8-(4-methylpiperazin-1-yl)-4-oxo-1-azatricyclo[7
14H2/t13-/m1/s1
A-674563 is a potent
Bendamustine has potent alkylating
InChi: InChI=1S/2C32H40N4O3
MIPS-521 Catalog No.:M33388-100 Chemical Name: 7-fluoro-12-methyl-8-(4-methylpiperazin-1-yl)-4-oxo-1-azatricyclo[7MIPS 521 is a positive allosteric modulator of the A1R, exhibits analgesic efficacy in rats in vivo through modulation of the increased levels of endogenous adenosine that occur in the spinal cord of rats with neuropathic pain. We also report the structure of the A1R co bound to adenosine, MIPS521 and a Gi2 heterotrimer, revealing an extrahelical lipid detergent facing allosteric binding pocket that involves transmembrane helixes 1, 6 and 7. Molecular
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