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YKL-5-124 TFA Catalog No.:M14492-2 activates Nrf2/ARE signal and exerts

SKU: 94213238991

4.4
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Description

activates Nrf2/ARE signal and exerts neuroprotective effects against 6-hydroxydopamine (6-OHDA)-induced oxidative stress and apoptosis

radiation alone

Ouabain octahydrate is a steroid hormone that inhibits Na(+)/K(+) ATPase

PubMed PMID: 27681596

(2015) Science

YKL-5-124 TFA Catalog No.:M14492-2 activates Nrf2/ARE signal and exertsYKL 5 124 TFA is a potent, selective, irreversible and covalent CDK7 inhibitor with IC50s of 53. 5 nM and 9. 7 nM for CDK7 and CDK7 Mat1 CycH, respectively. YKL 5 124 TFA is >100 fold greater selective for CDK7 than CDK9 and CDK2, and inactive against CDK12 and CDK13. YKL 5 124 TFA induces a strong cell cycle arrest, inhibits E2F driven gene expression, and exhibits little effect on RNA polymerase II phosphorylation status. Product information

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