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Fasudil Hydrochloride (100 μM) inhibits cell spreading
is a cardiac specific myosin activator
UK5099 reduces ATP levels and increases ADP and AMP levels in 832/13 cells
and Bcl-xl levels with upregulation of pErk and pAkt levels indicating cross talk between signaling pathways
InChi: InChI=1S/C12H13NO2/c14-12(15)7-3-4-9-8-13-11-6-2-1-5-10(9)11/h1-2
PFI-2 Hydrochloride 60099 Fasudil Hydrochloride (100 μM) inhibitsPFI 2 is a potent inhibitor of SETD7 with IC50 2 nM and 1000 fold selectivity over other methyltransferases and other non epigenetic targets. PFI 2 has been shown to bind to SETD7 by ITC (Kd=18nM) and biotinylated PFI 2 interacts with SETD7 in pull down studies. Its enantiomer (S) PFI 2 is 500 fold less active making it an excellent negative control. Treatment of low density MEFs with (R) PFI 2 resulted in higher nuclear YAP levels indicating an
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