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The EC50 of NSC59984 in most cancer cells is significantly lower than those of normal cells
EGylated naloxol
3'-bipyrrole]-2-carbonyl]phenol
Formula: C24H22N4O3
SSTC3 exhibits minimal gastrointestinal toxicity compared to other classes of WNT inhibitors
WP1066 Size:Solid 2 mg The EC50 of NSC59984 inWP1066 is a Stat3 inhibitor and JAK2 inhibitor. WP1066 is also a novel analogue of the JAK2 inhibitor AG490, in JAK2 V617F positive erythroleukemia HEL cells and in blood cells from patients with polycythemia vera. WP1066 significantly inhibited JAK2 and its downstream signal transducer and activator of transcription 3, signal transducer and activator of transcription 5, and extracellular signal regulated kinase 1 2 pathways in a dose and time