PF-06282999 - CAS# 1435467-37-0 size:10mg solid which is slightly more than

which is slightly more than the Ki of 4 nM for MRCKβ

PubMed PMID: 25824043

3109/00498254

2018 Jun 5

12(7):531-8

PF-06282999 - CAS# 1435467-37-0 size:10mg solid which is slightly more thanPF 06282999, CAS No. 1435467 37 0, is a potent and selective myeloperoxidase Inhibitor which is potential useful for the Treatment of Cardiovascular Diseases. PF 06282999 displayed excellent oral pharmacokinetics in preclinical species and robust irreversible inhibition of plasma MPO activity both in human blood stimulated exogenously and in plasma collected after oral (po) administration to lipopolysaccharide (LPS) treated cynomolgus monkeys. PF