So any six-mana threat you want to play has to be able to single-handedly snatch victory from the brink of defeat and very few creatures are good enough for that
Like former Aether Vial partner-in-crime Serra Avenger, the Chimera can come down as your second spell on turn 3, at which point a 3/3 flyer is quite a good rate
One of the best Mardu commanders and specifically an amazing extra-combat commander, Isshin excels at copying attack triggers
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It has good stats for its cost, provides minor, repeatable graveayrd hate, and even gives you cost reduction with the right set-up