If used properly, and with bounce back cards like the ones previously mentioned, this card can derail almost anything, and continue to do so as long as you have the ability to return it back to your hand
A remote island
Since the deck is not very fast and usually needs to catch up a little bit, Omnath, Locus of Creation is a perfect fit since he is great in making up some ground after having fallen behind
This means that Emrakul can't be hit with Erode, On Thin Ice, Blasphemous Act, or Banisher Priest, and basically is only vulnerable to sacrifice effects
Players are advised to include cards that protect their commander, like Swiftfoot Boots to give it hexproof or Commander's Plate to give it protection from blue, black and red spells
That said, if they have a bajillion mana, it doesnt matter