How much to play around B2B/Moon is all about percentages
In a game like MTG where clarity matters so much, this has concerned many MTG players
Pitch-perfect synergy exists between Nashi and cards like Scheming Symmetry , Varragoth, Bloodsky Sire , and the wretchedly terrifying Brainstealer Dragon
In fact, many of the best stuff running around is oriented toward the big side (Stoneforge Mystic, Restoration Angel, Teferi, Mage of Zhalfir, Consecrated Sphinx, Vampire Nighthawk, Gray Merchant of Asphodel, Feldon of the Third Path, Azusa, Lost of Seeking, Silklash Spider, Courser of Kruphix, Prophet of Kruphix, Brago, King Eternal, Kuldotha Forgemaster), and thats in addition to creatures specifically designed and included for defense like Walls and other cards with defender
Start to lay out builds, and try to include your best cards
Then its all about figuring out how to defeat your opponents card choices: Three knockouts of any kind on your opponent, and you win the match