It stands out even in White, which has the largest range of board wipes to choose from
It comes with an alternate casting cost of just one black if there are 13 or more creatures in play, which is pretty easy to hit in Commander
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Between this and the philosophy that multicolor cards can draw upon multiple parts of the color pie for their effects, the roles of multicolor cards are somewhat more malleable than those of their monocolor counterparts, as recently demonstrated by Wizards of the Coast when designing the colleges of Strixhaven
Kharn fits right into both of these commanders