Counters are suddenly dead cards, suspend spells are not castable anymore, and waiting for your opponent to make a move stops being an option
A bit of research will also allow you to more or less standardize the price of each bulk set
You can argue if you want, but many games come down to the first person to land and keep a Primeval Titan, and his effect pushes you way ahead in mana as others scramble to answer him and catch up singlehandedly
Blood Moon Ursalunas Season Skill ability reduces the cost of Blood Moon for each Prize Card your opponent has taken, making it easy to build up and turn the tides of battle late in the game
Of those, the top picks as highlights in Fourth Edition are of course, Killer Bees, Marsh Viper and Whirling Dervish
Within that stack should be no more than four of each card type