Desynchronization has a splashy enough effect to potentially see Modern play in the sideboard of a deck like Affinity, but it is, once again, going to be very meta-dependent
A special shout out to Dorian who went above and beyond
However, in Modern through Vintage, the card was an absolute powerhouse

Abyssal Gorestalker Abyssal Harvester Abzan Devotee Aclazotz, Deepest Betrayal Acolyte of Aclazotz Adorned Crocodile Adventurous Eater Agate-Blade Assassin Agency Coroner Agent Venom Agents of HYDRA Aggressive Negotiations Aggressive Symbiosis Ahriman Al Bhed Salvagers Alchemist's Assistant Alesha's Legacy Alien Symbiosis Alley Assailant Alpharael, Stonechosen Ambush Gigapede Anchovy & Banana Pizza Ancient Vendetta Another Chance Appendage Amalgam Arbiter of Woe Arcane Omens Archenemy's Charm Ardyn, the Usurper Armaggon, Future Shark Arnim Zola, Bio-Fanatic Arnyn, Deathbloom Botanist Ashiok's Reaper Ashiok, Wicked Manipulator Auntie's Sentence Avenger of the Fallen Azula Always Lies Azula, On the Hunt Back for Seconds Back on Track Bake into a Pie Balemurk Leech Bandit's Talent Bane-Marked Leonin Barbed Bloodletter Barbed Servitor Baron Helmut Zemo Baron Strucker, HYDRA Overlord Barrow Naughty Basilica Stalker Beamsaw Prospector Bebop, Warthog Warrior Beetle-Headed Merchants Behold the Sinister Six

For those who dont know, layers take on the role of Illumineer, giving them the power to wield six magical inks to summon glimmers (Disney characters and items)
An odd card, but worth checking out if you like experimenting with a number of different gameplay variants