If any part of that creature's head is higher than the bottom of the bar (that is, if it would hit the bar), the creature is a legal target
I expect that your ability and willingness to buy pretty much everything, including bulk common/uncommons and bulk rares will sway people in your favor who want to get rid of everything in one fell swoop
Maybe Niv-Mizzet will find his spark and come to Zendikar, but that seems unlikely to me
The best MTG Arena decks in Standard are: Simic Ouroboroid Izzet Lessons Dimir Excruciator Izzet Looting Mono Red Aggro Sultai Reanimator Dimir Midrange Selesnya Landfall Frequently Asked Questions Simic Ouroboroid An archetype that has been evolving ever since Edge of Eternity printed its namesake card, Ouroboroid is so Simicy I keep searching the decklist for Uro, Titan of Nature's Wrath and Growth Spiral (don't worry, they're not in Standard)
Early experiments were disastrous
Theoretical Duplication is a fantastic way to keep up with any opponent that tries to advance too quickly, or just to grab yourself a copy of a sweet creature your opponent is getting