Usually Demonic Tutor is the superior choice, but I actually like having the option to cast Vampiric Tutor in response to Terras Trance trigger if theres a card wed prefer to tutor into the graveyard
Ephemerate is one of those cards, which can be either non-existing or almost dominate the format , so I currently see it in between being really good in 4c Elementals/Omnath and Esper Reanimator
Like Disdainful Stroke or (honorable mention to this list) Essence Scatter, Negate earns its two-mana price tag by limiting the range of spells it can answer
This list is for kitchen table play with multiplayer, Type Four, Commander and Five Color in the conversation
These cards can sell for thousands of dollars, reflecting their enduring appeal.
This one is certainly for higher powered Cubes, but a discounted Gilded Lotus is most welcome there