There arent a ton of cards that stand out from the set on their own merits, but the set is deep with synergies and cool themes, so before I get into my Top 10 list, lets talk about these themes more broadly
Two theme decks Breakthrough and Steeplechase were also released for this series
If you have valuable cards that are rotating out and you dont intend to play the Expanded format, you might consider trading or selling them before their price potentially drops
The Value Hits The biggest financial hit among the Secrets of Strixhaven Special Guests is Sylvan Library, and its not close
If your opponent has a really good hand and you don't want them to have too many options, you can play Judge to force them to shuffle their hand back into their deck and draw four new cards
Pokemon TCG Pocket (PTCGP) Strategies & Guides Wiki Cards Space-Time Smackdown Dialga ex Crown Rare Art Card - Space-Time Smackdown