There are a few drawbacks to keep in mind
Across formats, all versions of Niv-Mizzet, Reborn decks either naturally meet Jegantha's restriction or can with very slight changes (mostly to their removal package, as the Modern and Pioneer builds often play a copy or two of Supreme Verdict)
You can then recast for free that exiled card with Quintorius later by paying three mana and sacrificing a Spirit
Players with suicidal propensity may target themselves, clever ones will choose not to cast the spell as the Miracle trigger resolves
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Its a staple in graveyard-centric strategies and a must-have in many decks