Any player can pay four mana to remove one of those counters, and they can do it during any upkeep
In theory, you could play 19 other cards in a single turn, and then play Grapeshot to deal 20 damage to your opponent
Mime TEU 66, have both rotated out the Standard format, but their interaction still exists in the Expanded format.) If youre unsure about whether a card youre interested in using from an older set is legal to use, PokGym has a helpful list that details which cards from previous sets are currently legal to use in the Standard format
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But effects like Bandits Talent, Go Blank and Liliana of the Veil do not give you the luxury of choosing your targets
And if youre running Teshar, Ancestor's Apostle as your historic commander then youre already in this territory anyway