The only potential problem is the fact that it is a Supporter card, and only one Supporter can be used per turn
Ive added a mix of small creatures that can come in early, like Blighted Agent and Plague Myr, as well as the original chonking infect issue, Skithiryx, the Blight Dragon
Illustrated by Greg Hildebrandt (misprinted) Standard Not Legal Alchemy Not Legal Pioneer Not Legal Historic Not Legal Modern Legal Brawl Not Legal Legacy Legal Comp
But yes, AYAYA is a great card here
Also, as a more contextual point, not all decks can support a Chalice, depending on their curve
Hold your finger along the top of your card and run it down, pushing the air out of the gap at the bottom