A permanent is any object on the battlefield, including tokens and lands
Single-target pump spells are rarely seen in Commander outside of Poison decks, because their effect - helping a single creature win a single combat - is so small compared to the infinite combos, massive token armies, and other nonsense that the format is known for
You dont lose the game when you get run down to zero life
Vial Smasher the Fierce seems like it would work better with Ludevic, Necro-Alchemist (and I honestly thought about pairing those two together at first), but hear me out
Having Hexproof is nice and makes you feel safe, but I ran Aegis of the Gods in Azor for years and it almost never saved me from anything, not only because having hexproof isn't as strong as it seems but also because people will want to kill it very quickly if they do need to target you
Sephiroth, Fabled SOLDIER / Sephiroth, One-Winged Angel Death triggers and life loss go hand in hand, and they rarely look better than on Sephiroth, Fabled SOLDIER