I highly recommend running a lot more ramp than you think you should (and a few ways to grant Haste!)
All Leader Cards come in new combinations of multi-colored cards to expand the range of play!
With the potential for an even bigger game world, better graphics, and utilizing the numerous cards from the current meta, there are a lot of possibilities as to what a new game could entail
Like we saw with Mizzix, this is hard to answer since if you kill her, you can recast her, and she is in Cabal Coffers and Rampant Growth colors so you have the mana
19 Will Phyrexia: All Will Be One Coming Out In 2023 Have Box Toppers
a nice effort of trying to get the 'four is death' trope, but the pronunciation is kind of very far from the mark