Strategies that usually benefit from being monocolor, like aggro, are weakened in Commander, due to the formats increased life total and multiple players
Most collectors send 20+ cards per submission
While Isochron Scepter and most other cards that create copies of cards allow you to cast them from exile, Kefnet allows you to cast the copy from your hand
For Mega Evolutions that usually have 200+ HP, the Lucky Ice Pop can make them unkillable
The Lost Caverns of Ixalan features four Commander decks, highlighting the competing factions of Ixalan attempting to reach the planes core
One thing is consistent, however: Not one of them has a hard once per turn clause, and this is where exploitation becomes extremely possible