It often sees play with red rummage cards like Artist's Talent and Tersa Lightshatter as enablers, although blue has plenty of looting effects to make it tick
However, there are other ways to use Food than just mere lifegain
Any abilities it has that interact with loss of life, such as that of Platinum Emperion, apply to that loss of life
Most spellslinger commanders directly interact with the cards in question
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Mutate turns two or more creature cards into one permanent, merging their abilities, and usually granting a special benefit when you do so - but the specific wording of the rules generates many edge cases you need to be aware of