It shuts down life gain, so there's no recovering from the punch it delivers
Whether youre a TCG fan looking forward to the new play elements that this expansion brings or someone in for the art like I am, Disney Lorcana: Into the Inklands is another winner
But you are ramping in green and you likely cast this and a creature, and this is both harder to kill and has a way better effect than the other cards in the Oracle of Mul Daya range
Besides hosting a Panharmonicon ability, known and loved by a majority of the Commander community, Virtue of Knowledges biggest boon may actually be its Vantress Visions Adventure spell, which can function as mono-blue ramp, among other things
Blood Moon especially can be backbreaking against multi-color decks with lots of nonbasic Lands
You won't see Griselbrand coming back from the graveyard in Commander, though, since it's banned in EDH